Workflow Optimization of the ViroSeq™ Human Immunodeficiency Virus-1 (HIV-1) Genotyping System
(Hum Virol Retrovirol 2015, 2(7); 00071) Summary: The study evaluated workflow organization and automation improvements to the ViroSeq HIV-1 Genotyping System through the use of semi-automated extraction platforms, automated amplicon quantification, and high-throughput sequencing platforms.
Novel Plasma Separation Cards for Collection in Resource-Limited Settings
(Presented at 2015 AMP in Austin, TX) Summary: This study evaluated the functionality and performance of a novel prototype plasma separation card that collects capillary blood, separates cellular components by gravity and stores plasma at ambient temperature pending analysis.
Detection of Inflammatory Biomarkers in Urine using a Dried, Shelf Stable Transport Device, ViveST®
Presented at 2015 ASN in San Diego, CA) Summary: This study described the detection of CXCL9/MIG and CXCL-10/IP-10 in urine spectrophotometrically, in combination with a novel collection device ViveST, eliminating the need for cold chain storage.
Room Temperature Stable, Dry-Transport Technology for Molecular Diagnostic Controls
(Presented at 2015 CVS in Daytona Beach, FL) Summary: In this study sets of molecular diagnostic controls were analyzed in their native frozen state and compared to controls stored on ViveST in a dried, thermostable format.
Proof of Concept: Novel Plasma Separation Cards for HCV/HIV Quantification
(Presented at 2015 HEP DART in Maui, HI) Summary: This study evaluated the performance of a novel prototype plasma separation card composed of a polysulfone separation membrane and absorbent collection pad allowing the separation of cellular components and collection/stabilization of plasma at ambient conditions.
Validation of Real-Time PCR Assay for HLA-B*5701 Detection: A Novel and Rapid Pharmacogenomic Test Predicting Abacavir Hypersensitivity Reaction
(Presented at 2014 CVS in Daytona Beach, FL) Summary: A description of the analytical performance of a real-time PCR assay for the detection of the HLA-B*5701 allele.
Ambient Temperature Shipping and Storage for Molecular Infectious Disease Testing: ViveST®
(Presented at 2014 AMP in Washington, D.C.) Summary: This study evaluated the stability of HIV-1 plasma samples shipped and stored on ViveST, a trasnformational dried ambient temperature storage and transportation device.
Proof of Concept: Plasma Separation Cards for Collection in Resource-Limited Settings
(Presented at 2014 AMP in Washington, D.C.) Summary: This study evaluated the stability of HIV-1 plasma samples shipped and stored on ViveST, a transformational dried ambient temperature storage and transportation device.
ING116070: A Study in Pharmacokinetics and Antiviral Activity of Dolutegravir in Cerebrospinal Fluid in HIV-1-infected, ART-Naive Subjects
(Clinical Infectious Diseases Advance Access publication published June 18, 2014) Summary: Median dolutegravir concentrations in cerebrospinal fluid were similar to unbound dolutegravir concentrations in plasma and in all subjects exceeded the in vitro 50% inhibitory concentration for wild-type viruses (0.2 ng/mL) by ≥ 66-fold, suggesting that dolutegravir achieves therapeutic concentrations in cerespinal fluid. HIV-1 SuperLow Viral […]
Detection of Low Level HCV RNA in Room Temperature Stored Samples using ViveST™, a Transformational Storage and Transport Device
(Presented at 2014 CVS in Daytona Beach, FL) Summary: This study evaluated the storage of low titer HCV plasma using ViveST, a transformational dried storage and transport device, in combination with the Abbott RealTime HCV assay.